Coronaviruses: An Essential Guide

Coronaviruses: what are they? And what do we know about them?

Here we present background information on coronaviruses as well as a timeline of the discovery and important developments related to coronaviruses.

What are coronaviruses?

Coronaviruses are RNA viruses that have characteristic club-shaped spikes projecting from their surface. Viewed through an electron microscope, they are said to be reminiscent of the solar corona from which they get their name.

There are 4 distinct genera of coronavirus: 

alphacoronavirus, betacoronavirus, gammacoronavirus and deltacoronavirus.

Within the betacoronaviruses, which includes SARS-CoV-2, there are four subgroups, A-D.​

There are 4 distinct genera of coronavirus: 

alphacoronavirus, betacoronavirus, gammacoronavirus and deltacoronavirus.

Within the betacoronaviruses, which includes SARS-CoV-2, there are four subgroups, A-D.

Coronavirus family tree

Source: Patrick C. Y. Woo, Yi Huang, Susanna K. P. Lau, and Kwok-Yung Yuen - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185738/, CC BY 3.0,

There are six known species of human coronaviruses, one of which is subdivided into two different strains, making seven different human coronaviruses. Four of these cause generally mild symptoms of the common cold: HCoV-229E, -NL63, -OC43 and -HKU1 continually circulate in the human population causing respiratory infections worldwide.

  1. Human coronavirus OC43 (HCoV-OC43) of the genus β-CoV
  2. Human coronavirus HKU1 (HCoV-HKU1), β-CoV,
  3. Human coronavirus 229E (HCoV-229E), α-CoV
  4. Human coronavirus NL63 (HCoV-NL63), α-CoV

Three strains (two species) produce symptoms that can be severe; all three of these are β-CoV strains:

  1. Middle East respiratory syndrome-related coronavirus (MERS-CoV)
  2. Severe acute respiratory syndrome coronavirus (SARS-CoV)
  3. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

The coronaviruses that cause disease in chickens, such as avian infectious bronchitis virus (IBV – a gammacoronavirus), and pigs, such as porcine respiratory coronavirus (PRCV – an alphacoronavirus) belong to different genera than the coronaviruses that cause potentially severe disease in humans: MERS-CoV, SARS-CoV and SARS-CoV-2 are all betacoronaviruses (see coronavirus family tree).

Because the avian coronaviruses and COVID-19 belong to two different groups of coronaviruses, it is highly unlikely that avian coronaviruses will infect humans, or vice-versa.

Coronavirus: key events timeline

Infectious bronchitis of chickens first described as a respiratory disease of chickens

  • 1931

Source: 

Jane K. A. Cook, M. Jackwood & R. C. Jones (2012) The long view: 40 years of infectious bronchitis research, Avian Pathology, 41:3, 239-250

1931
1936

Viral cause of infectious bronchitis established

  • 1936

Source: 

Jane K. A. Cook, M. Jackwood & R. C. Jones (2012) The long view: 40 years of infectious bronchitis research, Avian Pathology, 41:3, 239-250

First coronavirus (HCoV-229E) isolated from humans – initially named B814

  • 1965

Source:

Tyrell, D.A.J. & Bynoe, M.L. (1966) Cultivation of viruses from a high proportion of patients with colds. The Lancet, 287 (7428), 76-77

1965
1967

Almeida and Tyrrell performed electron microscopy on B814 and found particles that resembled the infectious bronchitis virus (IBV) of chickens, widely spaced club-shaped surface projections

  • 1967

Source:

Almeida JD & Tyrrell DA. (1967) The morphology of three previously uncharacterized human respiratory viruses that grow in organ culture. J Gen Virol. 1967 Apr;1(2):175-8.

Tyrrell led virologists working with the human strains and a number of animal viruses: infectious bronchitis virus, mouse hepatitis virus and transmissible gastroenteritis virus of swine. All were demonstrated to be morphologically using electron microscopy

  • Late 1960s

Source:

McIntosh K, Becker WB, Chanock RM (1967) Growth in suckling-mouse brain of "IBV-like" viruses from patients with upper respiratory tract disease. Proc Natl Acad Sci U S A. 1967 Dec;58(6):2268-73.

Late 1960s
1975

Officially accepted as a new genus of viruses, this new group of viruses was named coronavirus -corona referring to the crown-like appearance of the surface projections

  • 1975

Source:

Tyrrell, D.A.J. et al. (1975) Coronaviridae. Intervirology, 5: 76-82

Genome of a coronavirus (IBV) is shown to be a positive single stranded RNA

  • 1977

Source:

Lomniczi, B., & Kennedy, I. (1977). Genome of infectious bronchitis virus. Journal of virology24(1), 99–107.

1977
1983

Structure of IBV spike protein determined comprising two glycopolypeptides, S1 and S2

  • 1983

Source:

Cavanagh, D. (1983) Coronavirus IBV: Structural Characterization of the Spike Protein. Journal of General Virology, 64, 2577-2583.

First full genome sequence of a coronavirus (IBV) published

  • 1987

Source:

Boursnell et al. (1987) Completion of the Sequence of the Genome of the Coronavirus Avian Infections Bronchitis. Journal of General Virology, 68, 57-77.

1987
November 2002

Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in humans. Most probably originated in bats, was transmitted to palm civets and then to people in wet markets in southern China

  • November 2002

SARS-CoV outbreaks occurred in Hong Kong, Hanoi, Toronto, and Singapore. All could be directly traced back to index patient who acquired the infection in Guangdong and travelled to Hong Kong. 8096 people became ill, and 774 people died in this first SARS epidemic

  • 2003
2003
2003

In addition to significant morbidity and mortality, the SARS pandemic resulted in economic costs of an estimated USD 100 billion USD

  • 2003

Source:

Al-Tawfiq, J.A., Zumla, A., Memish, Z.A., 2014. Travel implications of emerging coronaviruses: SARS and MERS-CoV. Travel Med. Infect. Dis. 12 (5), 422–428.

Dozens of new coronaviruses isolated from bats

  • 2005 onwards

Source:

Korsmann, S.N.J. (2012) Virology. Churchill Livingstone.

2005 onwards
April 2012

First known case of MERS identified in Jordan by retrospective investigations

  • April 2012

Middle East Respiratory Syndrome (MERS) is caused by a coronavirus called Middle East Respiratory Syndrome Coronavirus (MERS-CoV). Most MERS patients developed severe respiratory illness with f fever, cough and shortness of breath; 3 or 4 out of every 10 patients reported with MERS died.

First report of MERS in Saudi Arabia

  • September 2012
September 2012
May 2014

2 cases of MERS confirmed in the US. Both patients were healthcare providers who had recently travelled from Saudi Arabia. Both fully recovered.

  • May 2014

Largest outbreak of MERS outside the Arabian Peninsula occurred in the Republic of Korea, associated with a traveller returning from the Arabian Peninsula

  • 2015
2015
November 2019

To date, 2494 confirmed cases of MERS have been reported and 858 deaths. Since peak of cases in 2014, there have been small numbers of cases each year, mostly in Saudi Arabia

  • November 2019

Symptom onset date of the first COVID-19 patient in Wuhan, China

  • 1 December 2019
1 December 2019
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